Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC046
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-12 12:33
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 4x1/4 caps Madopar HBS jedna uvece old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 25 individuals with a value less than 0.6 were subsequently diagnosed with PD. That is, 59.52% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.6 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 8, 'TN': 9, 'TP': 34, 'FP': 21}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 6, 'TN': 5, 'TP': 36, 'FP': 25}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 7, 'TP': 33, 'FP': 23}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 7.244
timePerCircleCoV 0.253221
timePerCircleSlope 0.017034
meanError 1.74669
tremorFreq 6.34766
tremorRelPower 29.9604
tremorGyroAmpMean 0.0156803
tremorGyroAmpSlope -0.0125011
tremorGyroAmpCoV 0.524296
tremorCoordAmpMean 0.0322021
tremorCoordAmpSlope -0.00270582
tremorCoordAmpCoV 0.290358
tremorAccAmpMean 0.0456456
tremorAccAmpSlope -0.000736358
tremorAccAmpCoV 0.0880116
tremorPcRelVar 0.65512
tremorPcX 0.297195
tremorPcY -0.954817

Circle Segment 1

Duration 4.92 s, Accuracy Estimate 3.387 (lower is better)

Circle Segment 2

Duration 6.12 s, Accuracy Estimate 1.494 (lower is better)

Circle Segment 3

Duration 6.88 s, Accuracy Estimate 1.435 (lower is better)

Circle Segment 4

Duration 6.72 s, Accuracy Estimate 1.142 (lower is better)

Circle Segment 5

Duration 10.64 s, Accuracy Estimate 1.622 (lower is better)

Circle Segment 6

Duration 7.36 s, Accuracy Estimate 1.692 (lower is better)

Circle Segment 7

Duration 10.32 s, Accuracy Estimate 1.685 (lower is better)

Circle Segment 8

Duration 7.04 s, Accuracy Estimate 1.286 (lower is better)

Circle Segment 9

Duration 6.4 s, Accuracy Estimate 1.504 (lower is better)

Circle Segment 10

Duration 6.04 s, Accuracy Estimate 2.221 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 16.08
timePerSpiralCoV 0.113565
timePerSpiralSlope -0.0163425
meanError 1.85443
tremorFreq 6.93359
tremorRelPower 33.7569
tremorGyroAmpMean 0.0162812
tremorGyroAmpSlope 0.00209629
tremorGyroAmpCoV 0.492325
tremorCoordAmpMean 0.0387973
tremorCoordAmpSlope 0.00128034
tremorCoordAmpCoV 0.288321
tremorAccAmpMean 0.0183246
tremorAccAmpSlope 0.000639379
tremorAccAmpCoV 0.471103
tremorPcRelVar 0.600213
tremorPcX -0.628406
tremorPcY -0.777885

Spiral Segment 1

Duration 20.6 s, Accuracy Estimate 1.624 (lower is better)

Spiral Segment 2

Duration 16.0 s, Accuracy Estimate 1.755 (lower is better)

Spiral Segment 3

Duration 15.56 s, Accuracy Estimate 1.777 (lower is better)

Spiral Segment 4

Duration 13.88 s, Accuracy Estimate 1.963 (lower is better)

Spiral Segment 5

Duration 15.4 s, Accuracy Estimate 1.872 (lower is better)

Spiral Segment 6

Duration 16.84 s, Accuracy Estimate 2.246 (lower is better)

Spiral Segment 7

Duration 16.8 s, Accuracy Estimate 1.814 (lower is better)

Spiral Segment 8

Duration 14.56 s, Accuracy Estimate 1.81 (lower is better)

Spiral Segment 9

Duration 15.8 s, Accuracy Estimate 1.842 (lower is better)

Spiral Segment 10

Duration 15.36 s, Accuracy Estimate 1.842 (lower is better)

Elel

eDurationMean 0.508
eDurationStd 0.074488
eDurationStdnorm 0.14663
eDurationMedian 0.4925
eDurationQuartdelta 0.0825
eDurationQuartdeltanorm 0.167513
eDurationKurt 6.35844
eDurationTrenddiff -0.06
eDurationTrendratio 0.886256
eWidthMean 7.17795
eWidthStd 2.31763
eWidthStdnorm 0.322881
eWidthMedian 6.7275
eWidthQuartdelta 2.808
eWidthQuartdeltanorm 0.417391
eWidthKurt 3.36024
eWidthTrenddiff 1.872
eWidthTrendratio 1.34043
eHeightMean 10.4891
eHeightStd 2.28529
eHeightStdnorm 0.217874
eHeightMedian 10.296
eHeightQuartdelta 2.691
eHeightQuartdeltanorm 0.261364
eHeightKurt 6.5915
eHeightTrenddiff 2.34
eHeightTrendratio 1.26316
eAspectMean 0.686584
eAspectStd 0.169927
eAspectStdnorm 0.247496
eAspectMedian 0.644661
eAspectQuartdelta 0.229544
eAspectQuartdeltanorm 0.356069
eAspectKurt 3.31258
eAspectTrenddiff -0.0245452
eAspectTrendratio 0.962917
eSlantMean 0.151493
eSlantStd 0.234203
eSlantStdnorm 1.54596
eSlantMedian 0.102867
eSlantQuartdelta 0.321174
eSlantQuartdeltanorm 3.12222
eSlantKurt 2.85716
eSlantTrenddiff -0.0838416
eRtopMean 0.745315
eRtopStd 0.101715
eRtopStdnorm 0.136472
eRtopMedian 0.73125
eRtopQuartdelta 0.140028
eRtopQuartdeltanorm 0.191491
eRtopKurt 2.22191
eRtopTrenddiff 0.00581897
eRbotMean 0.562867
eRbotStd 0.208063
eRbotStdnorm 0.369648
eRbotMedian 0.541958
eRbotQuartdelta 0.33057
eRbotQuartdeltanorm 0.609955
eRbotKurt 2.28804
eRbotTrenddiff 0.114303
eRrightMean 0.835877
eRrightStd 0.0735945
eRrightStdnorm 0.0880447
eRrightMedian 0.83233
eRrightQuartdelta 0.110445
eRrightQuartdeltanorm 0.132694
eRrightKurt 1.93848
eRrightTrenddiff 0.0209333
eRleftMean 0.330242
eRleftStd 0.102861
eRleftStdnorm 0.311473
eRleftMedian 0.319585
eRleftQuartdelta 0.15907
eRleftQuartdeltanorm 0.497741
eRleftKurt 2.07468
eRleftTrenddiff 0.065889
lDurationMean 0.718387
lDurationStd 0.155056
lDurationStdnorm 0.215839
lDurationMedian 0.65
lDurationQuartdelta 0.1575
lDurationQuartdeltanorm 0.242308
lDurationKurt 4.92649
lDurationTrenddiff -0.165
lDurationTrendratio 0.789809
lWidthMean 8.62781
lWidthStd 1.60933
lWidthStdnorm 0.186528
lWidthMedian 8.424
lWidthQuartdelta 2.07675
lWidthQuartdeltanorm 0.246528
lWidthKurt 3.39343
lWidthTrenddiff 1.17
lWidthTrendratio 1.14925
lHeightMean 22.6074
lHeightStd 2.07274
lHeightStdnorm 0.0916841
lHeightMedian 22.464
lHeightQuartdelta 2.48625
lHeightQuartdeltanorm 0.110677
lHeightKurt 5.71878
lHeightTrenddiff -1.17
lHeightTrendratio 0.948718
lAspectMean 0.382825
lAspectStd 0.0683554
lAspectStdnorm 0.178555
lAspectMedian 0.384236
lAspectQuartdelta 0.0705454
lAspectQuartdeltanorm 0.183599
lAspectKurt 3.29842
lAspectTrenddiff 0.0401687
lAspectTrendratio 1.11271
lSlantMean 0.050928
lSlantStd 0.106462
lSlantStdnorm 2.09043
lSlantMedian 0.0697674
lSlantQuartdelta 0.128785
lSlantQuartdeltanorm 1.84592
lSlantKurt 3.2639
lSlantTrenddiff 0.019464
lRtopMean 0.735424
lRtopStd 0.125535
lRtopStdnorm 0.170697
lRtopMedian 0.769231
lRtopQuartdelta 0.132126
lRtopQuartdeltanorm 0.171763
lRtopKurt 3.38199
lRtopTrenddiff -0.0335917
lRbotMean 0.629358
lRbotStd 0.20299
lRbotStdnorm 0.322535
lRbotMedian 0.619048
lRbotQuartdelta 0.226006
lRbotQuartdeltanorm 0.365086
lRbotKurt 3.70584
lRbotTrenddiff -0.0457971
lRrightMean 0.83943
lRrightStd 0.083319
lRrightStdnorm 0.0992566
lRrightMedian 0.856354
lRrightQuartdelta 0.0930853
lRrightQuartdeltanorm 0.1087
lRrightKurt 3.88775
lRrightTrenddiff -0.0334375
lRleftMean 0.306194
lRleftStd 0.13483
lRleftStdnorm 0.440341
lRleftMedian 0.285714
lRleftQuartdelta 0.147122
lRleftQuartdeltanorm 0.514927
lRleftKurt 4.19124
lRleftTrenddiff -0.0929842

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.986138
sumTouchScores 8.87524
meanMovementTime 0.85875
numTouches 9
undershootPercentage 0
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.908791
sumTouchScores 16.3582
meanMovementTime 1.06735
numTouches 18
undershootPercentage 0
overshootPercentage 22.2222

ZigZag

numZigzags 5
timePerZigzagMean 17.072
timePerZigzagCoV 0.0577591
timePerZigzagSlope -0.0304592
meanError 2.24599
tremorFreq 6.64062
tremorRelPower 24.7249
tremorGyroAmpMean 0.0215169
tremorGyroAmpSlope -0.00261507
tremorGyroAmpCoV 0.396086
tremorCoordAmpMean 0.0506787
tremorCoordAmpSlope 0.000668617
tremorCoordAmpCoV 0.274461
tremorAccAmpMean 0.0349542
tremorAccAmpSlope 0.000527517
tremorAccAmpCoV 0.318943
tremorPcRelVar 0.649723
tremorPcX -0.250154
tremorPcY 0.968206

ZigZag Segment 1

Duration 18.48 s, Accuracy Estimate 2.164 (lower is better)

ZigZag Segment 2

Duration 16.72 s, Accuracy Estimate 2.09 (lower is better)

ZigZag Segment 3

Duration 17.56 s, Accuracy Estimate 2.226 (lower is better)

ZigZag Segment 4

Duration 16.72 s, Accuracy Estimate 2.343 (lower is better)

ZigZag Segment 5

Duration 15.88 s, Accuracy Estimate 2.408 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 15.832
timePerZigzagCoV 0.129722
timePerZigzagSlope -0.0798383
zigzagHeightMean 72.9101
zigzagHeightCoV 0.0402725
zigzagHeightSlope 0.0244689
meanError 0.0354608
tremorFreq 6.83594
tremorRelPower 32.5585
tremorGyroAmpMean 0.0270352
tremorGyroAmpSlope -0.00065951
tremorGyroAmpCoV 0.388362
tremorCoordAmpMean 0.0589918
tremorCoordAmpSlope 0.0014582
tremorCoordAmpCoV 0.253153
tremorAccAmpMean 0.0412279
tremorAccAmpSlope 0.00105855
tremorAccAmpCoV 0.332654
tremorPcRelVar 0.682012
tremorPcX 0.0297635
tremorPcY 0.999557

ZigZag Offset Segment 1

Duration 17.88 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 2

Duration 17.84 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 3

Duration 15.6 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 4

Duration 14.72 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 5

Duration 13.12 s, Accuracy Estimate 0.059 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.6}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.4180586852631647}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8748594343901441}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6672511569026484}